Convergent functional genomic (CFG) is a method aiming at prioritizing AD candidate genes. CFG integrates AD related evidence including:
1) Genetic association of DNA variations with disease susceptibility;
2) gene expression regulated by AD genetic variants;
3) protein-protein interaction with AD core proteins, i.e. APP, PSEN1, PSEN2, APOE and MAPT;
4) diagnosis prediction of disease models.
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Matarin et al. A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology. Cell reports, 10(4): 633-644 (2015).
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