Expression profiles/differential expression results of individual studies/cross-platform normalized data




    Frontal Cortex


      GSE12685

      Citation: Williams et al. Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.
      PloS one, 4(3): e4936 (2009).

      GSE15222

      Citation: Webster et al. Genetic control of human brain transcript expression in Alzheimer disease.
      American Journal of Human Genetics, 84(4):445-458 (2009).

      GSE33000

      Citation: Narayanan et al. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.
      Molecular systems biology, 10(7): 743 (2014).

      GSE36980

      Citation: Hokama et al. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study.
      Cerebral cortex, bht101 (2013).

      GSE48350

      Citation: Berchtold et al. Gene expression changes in the course of normal brain aging are sexually dimorphic.
      Proceedings of the National Academy of Sciences, 105(40): 15605-15610 (2008).

      GSE5281

      Citation: Liang et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
      Physiol Genomics, 28(3):311-22 (2007).
      Liang et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
      PNAS, 105(11):4441-6 (2008).

      Cross-platform normalized (studies included: SE12685, GSE36980, GSE48350, GSE5281, GSE53890, GSE66333,GSE15222)

      Differential expression analysis of Cross-platform normalized dataset (stage-1)

      Differential expression analysis of Cross-platform normalized dataset (stage-2)


    Temporal Cortex


      GSE15222

      Citation:Webster et al. Genetic control of human brain transcript expression in Alzheimer disease.
      American Journal of Human Genetics, 84(4):445-458 (2009).

      GSE36980

      Citation: Hokama et al. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study.
      Cerebral cortex, bht101 (2013).

      GSE5281

      Citation: Liang et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
      Physiol Genomics, 28(3):311-22 (2007).
      Liang et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
      PNAS, 105(11):4441-6 (2008).

      GSE37263

      Citation: Tan et al. Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease.
      Journal of neuroscience research, 88(6): 1157-1169 (2010).

      Cross-platform normalized (studies included: GSE29652, GSE36980, GSE37263, GSE5281)

      Differential expression analysis of Cross-platform normalized dataset (stage-1)

      Differential expression analysis of Cross-platform normalized dataset (stage-2)

    Hippocampus


      GSE28146

      Citation: Blalock et al. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease.
      Journal of chemical neuroanatomy, 42(2): 118-126 (2011).

      GSE29378

      Citation: Miller et al. Genes and pathways underlying regional and cell type changes in Alzheimer's disease.
      Genome medicine, 5(5): 1 (2013).

      GSE36980

      Citation: Hokama et al. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study.
      Cerebral cortex, bht101 (2013).

      GSE48350

      Citation: Berchtold et al. Gene expression changes in the course of normal brain aging are sexually dimorphic.
      Proceedings of the National Academy of Sciences, 105(40): 15605-15610 (2008).

      GSE5281

      Citation: Liang et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
      Physiol Genomics, 28(3):311-22 (2007).
      Liang et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
      PNAS, 105(11):4441-6 (2008).

      Cross-platform normalized (studies included: Dataset of Hippocampus: GSE28146, GSE29378, GSE36980, GSE48350, GSE5281)

      Differential expression analysis of Cross-platform normalized dataset

    Entorhinal Cortex


      GSE26927

      Citation: Durrenberger et al. Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study.
      Acta neuropathologica, 124(6): 893-903 (2012).
      Durrenberger et al. Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.
      Journal of Neural Transmission, 122(7): 1055-1068 (2015).

      GSE48350

      Citation: Berchtold et al. Gene expression changes in the course of normal brain aging are sexually dimorphic.
      Proceedings of the National Academy of Sciences, 105(40): 15605-15610 (2008).

      GSE5281

      Citation: Liang et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
      Physiol Genomics, 28(3):311-22 (2007).
      Liang et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.
      PNAS, 105(11):4441-6 (2008).

      GSE26972

      Citation: Berson et al. Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice.
      EMBO molecular medicine, 4(8): 730-742 (2012).

      Cross-platform normalized (studies included: GSE26927, GSE26972, GSE48350, GSE5281)

      Differential expression analysis of Cross-platform normalized dataset

    Detailed information of all samples for differential expression analysis

    Gene connectivity in AD network / Control network

    RNA-seq data of YAP1 interference/overepression in U251-APP cells